IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 6519 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4079    
    Printed186    
    Emailed1    
    PDF Downloaded229    
    Comments [Add]    
    Cited by others 6    

Recommend this journal

 

 RESEARCH PAPER
Year : 2007  |  Volume : 39  |  Issue : 1  |  Page : 25-26

Solid plexiglass clips to induce reproducible renal hypertension in the rat


Department of Pharmacology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
A A Nekooeian
Department of Pharmacology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.30758

Rights and Permissions

Objective: The objective of this study was to induce reproducible renal hypertension in rats using plexiglass clips, and to compare it with that induced by silver clips. Materials and Methods: Saw blades (0.21-0.22 mm thick ) were used to make clips (4 x 2 x 2 mm) from a piece of 2-mm thick plexiglass. Rats were subjected to sham-operation or placement of plexiglass or silver clips around left renal artery, and 4 weeks later their mean blood pressure (MBP, mmHg), heart rate (HR, bpm), and heart weight (HW), left kidney weight (LKW), right kidney weight (RKW) and body weight (BW, g) were determined. The RKW, LKW and HW were calculated as a percentage of body weight. Results: Four weeks after sham-operation or placement of clips around renal artery, MBP, HW and RKW were significantly higher and LKW was significantly lower in left renal artery-clipped rats using plexiglass or silver clips than sham-operated ones. There was also no significant differnce among the values of HR or BW from the 3 groups. Moreover, there was no significant difference among MBP, HR, LKW, RKW or BW from sham-operated or renal artery-clipped rats. Conclusion: The findings suggest that placement of solid plexiglass clips around left renal artery resulted in hypertension comparable to that induced by silver clips.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow