| RESEARCH PAPER
|Year : 2006 | Volume
| Issue : 5 | Page : 350-354
In vivo and in vitro effects of the Canova medicine on experimental infection with Paracoccidioides brasiliensis in mice
G Takahachi1, MLF Maluf1, TIE Svidzinski1, MMO Dalalio1, CA Bersani-Amado2, RKN Cuman2
1 Department of Clinical Analyses, State University of Maringa, Brazil
2 Department of Pharmacy and Pharmacology, State University of Maringa, Brazil
Objective: To evaluate the in vivo and in vitro activity of Canova in experimental infection with Paracoccidioides brasiliensis.
Materials and Methods: Mice infected with P. brasiliensis were treated with Canova for 17 weeks. Follow-up measures included the determination of total antibodies, global and differential leukocyte counts. Further, nitric oxide production was determined by adding macrophage cultures to different concentrations of Canova in the presence or absence of P. brasiliensis.
Results: The data revealed the protective effect of Canova in P. brasiliensis- infected animals. A higher nitric oxide production was found in the Canova- treated cultures.
Conclusion: These data suggest that Canova activates the macrophages by a way that depends, at least in part, on nitric oxide.
Department of Pharmacy and Pharmacology, State University of Maringa
Source of Support: None, Conflict of Interest: None
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