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 RESEARCH PAPER
Year : 2006  |  Volume : 38  |  Issue : 5  |  Page : 341-345

Effect of eugenol on animal models of nociception


1 Department of Pharmacology, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune 411 038, India
2 Discovery Biology, Advinus Therapeutics, Bioresearch Centre, Pune 411057, Maharashtra, India

Correspondence Address:
S L Bodhankar
Department of Pharmacology, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune 411 038
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.27702

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Objective: To investigate the antinociceptive potential of eugenol on different pain models in mice. Materials and Methods : Eugenol was evaluated (1-100 mg/kg, i.p.) in various experimentally induced pain models like, formalin induced hyperalgesia, acetic acid induced abdominal constrictions, and thermal pain experiment using Eddy's hot plate. Results : Eugenol significantly inhibited acetic acid induced abdominal constrictions, with the maximal effect (92.73% inhibition) at 100 mg/kg. In formalin induced paw licking pain model, eugenol exhibited more pronounced antinociceptive effect in the inflammatory phase than the neurogenic phase (maximal effect was 70.33% and 42.22%, respectively, at 100 mg/kg, i.p). A mild reduction in the pain response latency at 100 mg/kg, i.p. dose of eugenol was observed in the hotplate thermal pain studies in mice. In the rotarod motor coordination experiment eugenol reduced the endurance time at the dose of 100 mg/kg, i.p. Conclusion: The data suggest that eugenol exerts antinociceptive activity in different experimental models of pain in mice.






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