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 RESEARCH PAPER
Year : 2005  |  Volume : 37  |  Issue : 4  |  Page : 243-246

Pharmacological screening and evaluation of antiplasmodial activity of Croton zambesicus against Plasmodium berghei berghei infection in mice


1 Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
2 Department of Pharmacognosy & Traditional Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
3 Department of Pharmacology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria

Correspondence Address:
J E Okokon
Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Uyo, Uyo
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.16571

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Objective: To evaluate the antiplasmodial activity of leaf extract of Croton zambesicus on chloroquine-sensitive Plasmodium berghei berghei infection in mice and to confirm its traditional use as a malarial remedy in Africa. Materials and Methods : The ethanolic leaf extract of Croton zambesicus (50-200 mg/kg) was screened for blood schizontocidal activity against chloroquine-sensitive Plasmodium berghei berghei infection in mice. The schizontocidal activity during early and established infections as well as the repository activity were investigated. Results: The extract demonstrated a dose-dependent chemosuppression or schizontocidal effect during early and in established infections, and also had repository activity. The activity was lower than that of the standard drugs (chloroquine 5 mg/kg, pyrimethamine 1.2 mg/kg/day). Conclusion: The leaf extract possesses considerable antiplasmodial activity, which can be exploited in malaria therapy.






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