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 RESEARCH PAPER
Year : 2005  |  Volume : 37  |  Issue : 4  |  Page : 227-231

In vitro antioxidant effect of Globularia alypum L. hydromethanolic extract


1 Laboratoire de Biochimie Appliquée et Biotechnologie. Faculté des Sciences, EL Jadida, Morocco
2 Research Center on Aging, Sherbrooke Geriatric University Institute, University of Sherbrooke, Sherbrooke, Que, Canada
3 Laboratoire de Chimie Organique et d'Etudes Physico-Chimiques, Ecole Normale Supérieure, Rabat, Morocco

Correspondence Address:
A El Abbouyi
Laboratoire de Biochimie Appliquée et Biotechnologie. Faculté des Sciences, EL Jadida
Morocco
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.16568

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Objective : To investigate the in vitro antioxidant activity of the hydromethanolic extract of aerial parts (leaves and stems) of Globularia alypum L. toward linoleic acid emulsion and human low-density lipoproteins (LDL) peroxidation. Materials and Methods : Lipid peroxidation was carried out in the presence of G. alypum hydromethanolic extract (10 and 100 µg of extract/ml). CuSO4 (10 µM) was used as the oxidation initiator. Conjugated dienes (CD) formation and oxygen consumption were assessed for monitoring the antioxidant properties of the plant extract. Butylated hydroxytoluene at 50 µg/ml was used as standard antioxidant. Quantification of total polyphenolic compounds was carried out according to the Folin-Ciocalteu method. Results : The hydromethanolic extract of G. alypum exhibited significant antioxidant effect. There was a significant inhibition of CD formation in copper ions-mediated linoleic acid emulsion as well as human LDL peroxidation. Analysis of the plant extract revealed a high amount of polyphenols, suggesting a possible role of these compounds in the antioxidant properties. Conclusion : The obtained results suggested that G. alypum could be a potential source of antioxidants. Further investigations are in progress to determine the active constituent(s).






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