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 RESEARCH PAPER
Year : 2005  |  Volume : 37  |  Issue : 1  |  Page : 33-36

Evaluation of CNS activity of Bramhi Ghrita


Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur - 440 033, India

Correspondence Address:
G S Achliya
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur - 440 033
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.13853

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OBJECTIVE: To eavaluate the CNS activity of Bramhi Ghrita, a polyherbal formulation containing Bacopa monneri, Evolvulus alsinoids, Acorus calamus, Saussurea lappa and cow's ghee. MATERIALS AND METHODS: The effect of Bramhi Ghrita on motor coordination, behavior, sleep, convulsions, locomotion and analgesia was evaluated in mice using standard procedures. RESULTS: The formulation exhibited reduced alertness, spontaneous locomotor activity and reactivity. It also antagonized the behavioral effects of d-amphetamine, potentiated the pentobarbitone-induced sleep and increased the pain threshold. Bramhi Ghrita protected mice from maximum electroshock and pentylene tetrazole-induced convulsions.






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