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 RESEARCH PAPER
Year : 2004  |  Volume : 36  |  Issue : 6  |  Page : 377-380

Antinociceptive and antiinflammatory effects of Centella asiatica


1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 UPM Serdang, Selangor, Malaysia
2 Laboratory of Natural Resources, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
3 Universiti Industri Selangor, Jalan Zirkon, Shah Alam, Selangor, Malaysia

Correspondence Address:
M N Somchit
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 UPM Serdang, Selangor
Malaysia
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Source of Support: None, Conflict of Interest: None


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OBJECTIVE: To evaluate the effects of Centella asiatica (CA) upon pain (antinociception) and inflammation in rodent models. MATERIAL AND METHODS: The antinociceptive activity of the water extract of CA (10, 30, 100 and 300 mg/kg) was studied using acetic acid-induced writhing and hot-plate method in mice. The antiinflammatory activity of CA was studied in rats by prostaglandin E2-induced paw edema. RESULTS: Water extract of CA revealed significant antinociceptive activity with both the models. The activity was statistically similar to aspirin but less potent than morphine. The CA extract also revealed significant antiinflammatory activity. This effect was statistically similar to the non-steroidal antiinflammatory drug, mefenamic acid. CONCLUSION: These results suggest that the water extract of CA possesses antinociceptive and antiinflammatory activities.






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