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 RESEARCH PAPER
Year : 2004  |  Volume : 36  |  Issue : 5  |  Page : 284-287

Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage


School of Biosciences, Mahatma Gandhi University, P. D. Hills, P. O., Kottayam - 686 560, India

Correspondence Address:
M S Latha
School of Biosciences, Mahatma Gandhi University, P. D. Hills, P. O., Kottayam - 686 560
India
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Source of Support: None, Conflict of Interest: None


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OBJECTIVE: To evaluate the potential efficacy of Glycyrrhiza glabra Linn. (Fabaceae) in protecting tissues from peroxidative damage in CCl4-intoxicated rats. MATERIAL AND METHODS: Peroxidative hepatic damage in rats was studied by assessing parameters such as thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD), superoxidedismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px) and glutathione (GSH) in liver and kidneys. The effect of co-administration of G. glabra on the above parameters and histopathological findings of the liver in experimental animals was studied. RESULTS: The increased lipid peroxide formation in the tissues of CCl4-treated rats was significantly inhibited by G. glabra. The observed decreased antioxidant enzyme activities of SOD, CAT, GSH-Px, GST, and antioxidant concentration of glutathione were nearly normalized by G. glabra treatment. Carbon tetrachloride-induced damage produces alteration in the antioxidant status of the tissues, which is manifested by abnormal histopathology. G. glabra restored all these changes. CONCLUSION: Glycyrrhiza glabra is a potential antioxidant and attenuates the hepatotoxic effect of CCl4.






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