IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1425 
Small font sizeDefault font sizeIncrease font size
Navigate Here
  Search
 
  Next article
  Previous article 
  Table of Contents
  
Resource Links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (57 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)

 
In This Article
   References

 Article Access Statistics
    Viewed3041    
    Printed153    
    Emailed3    
    PDF Downloaded205    
    Comments [Add]    

Recommend this journal

 
CORRESPONDENCE
Year : 2004  |  Volume : 36  |  Issue : 3  |  Page : 182
 

Novel therapeutic strategies for osteoporosis


Department of Pharmacology and Therapeutics, Govt. Medical College, Jammu, India

Correspondence Address:
Department of Pharmacology and Therapeutics, Govt. Medical College, Jammu, India
ujala_verma@rediffmail.com



How to cite this article:
Sharma R, Verma U, Sharma P. Novel therapeutic strategies for osteoporosis. Indian J Pharmacol 2004;36:182


How to cite this URL:
Sharma R, Verma U, Sharma P. Novel therapeutic strategies for osteoporosis. Indian J Pharmacol [serial online] 2004 [cited 2019 Aug 23];36:182. Available from: http://www.ijp-online.com/text.asp?2004/36/3/182/6880


This has reference to the article on the Molecules of the Millennium, entitled 'Novel agents in osteoporosis' published in the Indian Journal of Pharmacology, 2004;36:48-9. The article is very informative and interesting. The mechanism of the actions of selective estrogen receptor modulators (SERMs) in relation to regulation of the growth factor beta cytokines and the induction of osteoblasts with inhibition of osteoclasts, is well explained. However, there are few more novel SERMs having therapeutic advantages over raloxifene.
Ospemifene,[1] a derivative of foremifene with estrogen receptor (ER) blocking action on breast tissue and ER partial agonistic actions on bone and cardiovascular system, is being investigated for the treatment and prevention of osteoporosis. It has Cmax (maximum concentration) of 43 mg/L, tmax (time to achieve Cmax) of 1-4 h, t of 24 h after a single 50 mg dose per day. Various Phase I and Phase II clinical trials have demonstrated better results with ospemifene than raloxifene. It has the additional advantage of having an LDL lowering effect and a positive effect on vaginal dryness (ER agonist effect on the vagina). Moreover, no effect has been reported with its use, on blood clotting, hot flushes and insomnia.
Arzoxifene[1] is another benzothiophene derivative related to raloxifene with ER blocking effect on the breast and uterine tissue and ER partial agonistic effect on bone and cardiovascular system. However, various in vitro and in vivo studies have demonstrated the superiority of arzoxifene over tomoxifen in breast cancer. It has t of 30-35 h, Cmax of 4.67 mg/L and tmax of 2-6 h after a 50 mg single dose. It is also a potential candidate for the treatment and prevention of osteoporosis. However, the common side effects reported with its use are rash, pruritis, constipation, headache, nausea, vomiting, stomatitis and rarely, it can cause pulmonary embolus and deep vein thrombosis.
HMGCoA reductase inhibitor is another class of drug that is being investigated for its potential role in osteoporosis. Statins like lovastatin and simvastatin have demonstrated an increase in bone volume and rate of bone formation after oral therapy.[2] Soy-derived isoflavones are also being investigated as potential therapeutic agents in the prevention and treatment of osteoporosis.[3]
If the efficacy of these agents is proved, then there will be novel additions to the armamentarium of the physician against osteoporosis, especially in post-menopausal women. 

  References Top

1.Morello KC, Wurz GT, De Gregorio MW. Pharmacokinetics of selective estrogen receptor modulators. Clin Pharmacokinet 2003;42:361-72.  Back to cited text no. 1    
2.Vogel G. Cholesterol-lowering drugs may boost bones. Science 1999;286:1825-6.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Chen YM, Ho SC, Lam SSH, Ho SS, Woo JLF. Soy isoflavones have favourable effect on bone loss in Chinese post menopausal women with lower bone mass: A double blind, randomized, controlled trial. J Clin Endocrinol Metabolism 2003;88:4740-7.  Back to cited text no. 3    
Top
Print this article  Email this article

    

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow