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 RESEARCH PAPER
Year : 2004  |  Volume : 36  |  Issue : 1  |  Page : 38-40

Antitumor activity of Indigofera aspalathoides on Ehrlich ascites carcinoma in mice


1 Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Yercaud Road, Salem - 636008, India
2 Institute of Pharmacology, Madurai Medical College, Madurai - 625020, India

Correspondence Address:
B Rajkapoor
Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Yercaud Road, Salem - 636008
India
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Source of Support: None, Conflict of Interest: None


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Objective: To evaluate the antitumor activity of the ethanol extract of Indigofera aspalathoides (EIA) in mice. Material and Methods: The antitumor activity of EIA was evaluated against the Ehrlich ascites carcinoma (EAC) tumor model. The activity was assessed using survival time, peritoneal cell count, hematological studies, solid tumor mass and in vitro cytotoxicity. Results: Oral administration of EIA increased the survival time and normal peritoneal cell count. Hematological parameters, protein and PCV, which were altered by tumor inoculation, were restored. Solid tumor mass was also significantly reduced. EIA was found to be cytotoxic in the in vitro model. Conclusion: EIA possesses significant antitumor activity.






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