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 RESEARCH PAPER
Year : 2004  |  Volume : 36  |  Issue : 1  |  Page : 34-37

Protective effect of a polyherbal drug, ambrex in ethanol- induced gastric mucosal lesions in experimental rats


Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai - 600025, India

Correspondence Address:
C S Shyamala Devi
Old No. 62, New No.66, IInd Main Road, Gandhi Nagar, Adyar, Chennai - 600020,
India
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Source of Support: None, Conflict of Interest: None


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Objective: To investigate the protective effect of ambrex in ethanol-induced gastric mucosal lesions in rats. Material and Methods: Ethanol-induced gastric mucosal lesions in male Wistar rats were used to evaluate gastric ulcer protective effect of ambrex (40 mg/kg/day p.o. for 15 days). The response to ambrex was assessed from ulcer index, cell proliferation, histopathological changes and alkaline phosphatase (ALP) activity. Results: Ambrex pretreatment showed protection against ethanol-induced gastric mucosal damage, a significant reduction in the ulcer index and ALP activity, and an increase in the DNA content. Conclusion: Ambrex offers protection against ethanol-induced gastric ulcers.






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