| RESEARCH PAPER
|Year : 2004 | Volume
| Issue : 1 | Page : 34-37
Protective effect of a polyherbal drug, ambrex in ethanol- induced gastric mucosal lesions in experimental rats
S Narayan, RS Devi, M Jainu, KE Sabitha, CS Shyamala Devi
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai - 600025, India
Objective: To investigate the protective effect of ambrex in ethanol-induced gastric mucosal lesions in rats.
Material and Methods: Ethanol-induced gastric mucosal lesions in male Wistar rats were used to evaluate gastric ulcer protective effect of ambrex (40 mg/kg/day p.o. for 15 days). The response to ambrex was assessed from ulcer index, cell proliferation, histopathological changes and alkaline phosphatase (ALP) activity.
Results: Ambrex pretreatment showed protection against ethanol-induced gastric mucosal damage, a significant reduction in the ulcer index and ALP activity, and an increase in the DNA content.
Conclusion: Ambrex offers protection against ethanol-induced gastric ulcers.
C S Shyamala Devi
Old No. 62, New No.66, IInd Main Road, Gandhi Nagar, Adyar, Chennai - 600020,
Source of Support: None, Conflict of Interest: None
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