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 RESEARCH PAPER
Year : 2004  |  Volume : 36  |  Issue : 1  |  Page : 25-28

Single oral dose toxicity study of a-cypermethrin in rats


1 Department of Pharmacology, University College of Medicine, Calcutta University, Kolkata – 700020, India
2 Department of Pathology, West Bengal University of Animal and Fishery Sciences, 37, K. B. Sarani, Kolkata – 700037, India
3 Department of Pharmacology, West Bengal University of Animal and Fishery Sciences, 37, K. B. Sarani, Kolkata – 700037, India

Correspondence Address:
D Bhattacharyya
Department of Pharmacology, University College of Medicine, Calcutta University, Kolkata – 700020
India
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Source of Support: None, Conflict of Interest: None


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Objective: To evaluate the acute effect of a-cypermethrin (a-CP) on antioxidant activities, oxidants, biochemical and histopathological changes at LD50 dose level. Material and Methods: a-CP at single LD50 (145 mg/kg) dose was administered orally to Wistar rats while controls received an equal volume of the vehicle, DMSO. The antioxidants, oxidants, biochemical and histopathological changes in some visceral organs were studied following a-CP. Results: A single LD50 dose of a-CP increased the malondialdehyde (MDA) level and decreased the activities of catalase (CAT), superoxide dismutase (SOD) and glycogen in the liver. It also increased the serum aminotransaminases (AST, ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activities, and blood glucose level. It produced some cytotoxic effect on the lungs, liver, stomach, intestine, testes and cerebellum. The vehicle DMSO may have influenced the determination of LD50 of a-CP in rats. Conclusion: A single, oral LD50 dose of a-CP decreased antioxidant status, and altered biochemical parameters, which correlated with histopathological changes in rats.






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