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Year : 2002  |  Volume : 34  |  Issue : 3  |  Page : 198-201

The effect of captopril, prazosin and methyldopa on atherosclerotic plaque formation in hypercholesterolaemic rabbits



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Husaini Fallah


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1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.






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