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 SHORT COMMUNICATION
Year : 2002  |  Volume : 34  |  Issue : 3  |  Page : 184-188

The antinociceptive and antiinflammatory activities and lack of ulcerogenicity of a benzodioxin-4-one and its analog benzoxazine as cyclic acetal-like derivatives of salicylic acid and salicylamide in mice and rats



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1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes. 2. The degree of hemolysis is almost the same in both the erythrocytes. 3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA. 4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.






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