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 EDUCATIONAL FORUM
Year : 2002  |  Volume : 34  |  Issue : 2  |  Page : 86-89

Genotoxicity testing, a regulatory requirement for drug discovery and development: Impact of ICH guidelines



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Rao P Rama


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1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes. 2. The degree of hemolysis is almost the same in both the erythrocytes. 3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA. 4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.






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