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 SHORT COMMUNICATION
Year : 2000  |  Volume : 32  |  Issue : 6  |  Page : 372-374

Antinociceptive activity of Azadirachta Indica (neem) in rats



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P Khosla


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Objective: To study the antinociceptive effect of A.indica in rats. Methods: Analgesia was evaluated using tail flick reaction time to thermal stimulus and glacial acetic acid (GAA) induced writhing. A. indica leaf extract (500mg/kg) and A. indica seed oil (2ml/kg) were given orally by an intragastric tube. Naloxone was given to study the mechanism of antinociceptive effect. Results: Tail flick reaction time was significantly increased in rats with both leaf extract and seed oil. Naloxone pretreatment partially reversed the antinociceptive effect of leaf extract and seed oil. GAA induced writhing was reduced with both leaf extract and seed oil. Pretreatment with naloxone partially reversed the inhibitory effect of leaf extract and seed oil on GAA induced writhing. Leaf extract was more potent than seed oil. Conclusion: The results indicate that both the preparations of A. indica (leaf extract and seed oil) possess antinociceptive activity in rats, leaf extract being more potent.






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