IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1068 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4099    
    Printed84    
    Emailed1    
    PDF Downloaded562    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 2000  |  Volume : 32  |  Issue : 6  |  Page : 339-346

Anti-cataleptic, anti-anxiety and anti-depressant activity of gold preparations used in Indian systems of medicine



Correspondence Address:
Bajaj Sonia


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objectives: To study traditional gold preparations for anti-cataleptic, anti-anxiety and anti-depressant effects. Methods: Swarna Bhasma used in Ayurveda, Kushta Tila Kalan used in Unani-Tibb and Auranofin used in modern medicine were subjected to videopath analyzer, vogel conflict/anxiometer, elevated plus maze, and social behavioural deficit tests for anxiolytic activity, behavioural despair and learned helplessness tests for antidepressant activity, haloperidol-induced catalepsy tests for neuroleptic activity, and maximum tolerated dose, gross behavioural observations and hematological parameters for safety evaluation in rats and mice. Results: The test drugs caused significant increase in punished drinking episodes in anxiometer and open arm entries and time in elevated plus maze and decrease in behavioural deficit. A decrease in immobility time in forced swimming test, normalization of shock induced escape failures in learned helplessness test, and reduction of haloperidol-induced catalepsy scores were also noted in treated animals. The maximum tolerated doses were found to be more than 80 times the effective doses and no weight loss or untoward effects were observed on gross behaviour and hematological parameters. Conclusions: Traditional gold preparations used in Ayurveda and Unani-Tibb exhibited anxiolytic, antidepressant and anticataleptic actions with wide margin of safety.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow