IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 2227 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1729    
    Printed92    
    Emailed0    
    PDF Downloaded204    
    Comments [Add]    

Recommend this journal

 

 SHORT COMMUNICATION
Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 242-245

Effect of locomotor activity on the passive avoidance test for the evaluation of cognitive function



Correspondence Address:
Vohora Divya


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objective: To probe whether locomotor activity (LA) affects passive avoidance response (PAR) in mice Methods: PAR and LA were studied in mice treated with known amnesic (scopolamine, diazepam) and nootropic (piracetam, Bacopa monniera extract) drugs. For PAR, the step-down latency (SDL), step-down errors (SDE) and time spent in shock zone (TSZ) were measured. A videopath analyzer was used for recording LA. Results: An increase in LA augmented SDE scores and vice-versa, indicating a direct correlation. No such correlation was seen between LA and the other two parameters viz SDL and TSZ. The latter increased with amnesic agents and decreased in nootropic treated animals. Conclusion: LA affects parameters for evaluation of cognitive function by the PAR test. TSZ appears to be the best indicator for nootropic/amnesic activity.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow