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 RESEARCH PAPER
Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 226-230

Central nitrinergic system in Brewer s yeast induced peripheral inflammation in rats



Correspondence Address:
J Sarma


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Source of Support: None, Conflict of Interest: None


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Objective: To investigate the role of central nitrinergic system in Brewer's yeast induced peripheral inflammation in rats. Methods: Permanent icv cannulation in rats was performed stereotaxically into the right lateral ventricle under ketamine hydrochloride anaesthesia. NO modulators viz NO synthase inhibitors, NO precursor, NO donors and NO scavengers were administered icv 30 min prior to induction of paw oedema by injecting 0.1 ml of 20% (W/V) Brewer's yeast below the planter aponeurosis of hind paw in rats. Paw volume up to the ankle joint was recorded plethysmographically. Results: NO synthase inhibitors and NO scavenger haemoglobin (Hb) were found to be potent inhibitors of paw volume increase in the late phase (1-5 h) than early period (15-60 min). NO donors SIN-1, SNP and NO precursor L-arginine were found to increase the oedema volume. D- arginine and methylene blue were without any effect. Conclusion: Central nitrinergic system modulates the Brewer's yeast induced peripheral inflammation in rats. Both endogenous and exogenous NO are involved in the inflammatory process.






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