IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 646 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1320    
    Printed84    
    Emailed3    
    PDF Downloaded111    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 192-197

Sodium arsenite induced alteration in functional activity of murine peritoneal macrophages


Correspondence Address:
Bishayi Biswadev


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objective: To study the effect of sodium arsenite exposure on the functions of murine leukocytes and humoral immune response. Methods: Male (BALB/c) mice were continuously exposed to sodium arsenite (NaAsO2 ) for two weeks. Fractions of peritoneal macrophages were separated and their functional activities were determined. To test the effects of arsenic on the humoral immune response heat killed S.aureus was injected and the titre of the antiserum was measured. Results: The mean phagocytic index (P.I) of control macrophage (M() is decreased from 25571.43 ( 1126.26 to 4905.30 ( 556.70 after Sodium arsenite treatment, whereas the mean P.I of S. aureus primed M( (47147.44 ( 666.36) is also decreased to 15965.91 ( 1185.95 in case of arsenite exposure followed by S.aureus immunization (P<0.001). Intracellular killing capacity in control cell is (68.4%) which is found to be 77.3% in case of NaAsO2 treatment and they can kill only 22.7% bacteria. The chemotactic index also decreases significantly in case of arsenic treated cell (2.5( 0.02) with respect to that of control cell (9.83( 0.22) at 60 min. In S.aureus immunized serum, agglutination titre was obtained at lowest antibody conc(1:512), whereas serum from pre-exposure of arsenite followed by S.aureus immunization showed early agglutination (1:32). Conclusion: Sodium arsenite exposure interferes with the immunological functions and antibody raising capacity of peritoneal macrophages in BALB/C mice.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow