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 RESEARCH PAPER
Year : 2000  |  Volume : 32  |  Issue : 2  |  Page : 114-119

Effect of fish oil on cigarette smoking induced dyslipidemia in rats



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S Chitra


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Objective: To evaluate the effect of fish oil, on experimental animals exposed to cigarette smoke. Methods: Fish oil was administered orally to male albino rats at a dosage of 0.5 ml/kg b.wt/day to study the effect of fish oil in cigarette smoke exposed animals. During the experimental period ( i.e. 30 or 90 days) the animals were exposed to cigarette smoke for a period of 2 hr/day. At the end of 30 or 90 days the animals were sacrificed, serum was separated and tissues (heart and lungs) were used for the lipid extraction to analyse the biochemical parameters such as total cholesterol, triglycerides, free fatty acids, phospholipids and MDA levels. Results: Animals exposed to cigarette smoke for 30 or 90 days, resulted in the elevated levels of cholesterol and triglycerides in serum and tissues. No significant change was observed in the levels of free fatty acids in both 30 or 90 days of all four groups. The levels of phospholipid was found to be significantly decreased in serum and tissues of the experimental rats after smoke exposure. The above changes were prevented with simultaneous supplementation of fish oil in 30 or 90 days co-treatment. Conclusion: Administration of fish oil may prevent the cigarette smoke induced dyslipidemia in rats.






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