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 RESEARCH PAPER
Year : 2000  |  Volume : 32  |  Issue : 2  |  Page : 102-107

Effect of amiloride on ouabain induced arrhythmias in vivo in guinea-pigs


Correspondence Address:
D C Dhasmana


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Objectives: To examine the effects of amiloride on ouabain induced arrhythmias in anaesthetised adult, healthy, guinea-pigs. Methods: In acute studies, amiloride (10 mg/kg) was given intravenously before the onset of constant ouabain (8 (g/100(l/min) infusion, to induce ventricular premature beats (VPB), ventricular tachycardia and /or fibrillation with sudden fall in blood pressure (VT/F) and cardiac arrest (CA). Propranolol (2mg/kg, i.v.) was also studied against ouabain induced arrhythmia as a positive control. Changes in blood pressure (BP) and heart rate (HR) were monitored simultaneously in anaesthetised animals. In chronic studies, amiloride (10 mg/kg) was given intraperitoneally for three days followed by intravenously on fourth day, before ouabain infusion, as described above. Results: In acute as well as in chronic studies, no changes were observed in the quantity of ouabain required to produce arrhythmias after amiloride pretreatment. On the contrary, propranolol increased ouabain requirement very significantly. There were significant changes in BP and HR after amiloride administration in acute studies. In chronic studies also, similar changes were observed in BP and HR after intravenous administration of amiloride. Conclusion: Amiloride in the dosage studied in vivo did not protect the animal from ouabain induced arrhythmias.






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