| RESEARCH PAPER
|Year : 2000 | Volume
| Issue : 1 | Page : 21-24
Assessment of the anti-inflammatory effects of Swertia chirata in acute and chronic experimental models in male albino rats
Banerjee Shivaji, Kumar Sur Tapas, Mandal Suvra, Chandra Das Prabhash, Sikdar Sridhar
Objectives: To study the anti-inflammatory effect of xanthone derivative (1,5-dihydroxy-3,8-dimethoxy xanthone) of Swertia chirata (SC-I) in acute, sub-acute and chronic experimental models in male albino rats.
Methods: Aerial parts of Swertia chirata were extracted with organic solvent and purified by chromatographic procedure. SC-I was studied in carrageenin-induced hind paw oedema in rats and the paw volume was measured plethysmometrically at 0 and 3 h after injection. The compound was subjected to turpentine oil-induced granuloma pouch in rats. The pouch was opened on day 7 under anaesthesia and the exudate collected by a syringe was measured. The drug was also investigated in formalin-induced oedema models in rats. Degree of inflammation was measured plethysmometrically on day 1 and 7 and compared with control and standard drug, diclofenac. All the drugs were administered orally.
Results: The higher dose of SC-I significantly reduced carrageenin-induced pedal oedema (57%) and formalin-induced pedal oedema in rats (58%). SC-I also decreased exudate volume (35%) in turpentine oil-induced granuloma formation in comparison to control.
Conclusion: 1,5-dihydroxy-3,8-dimethoxy xanthone of Swertia chirata showed significant anti-inflammatory action in acute, sub-acute and chronic experimental models in rats.
Source of Support: None, Conflict of Interest: None