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Year : 1999  |  Volume : 31  |  Issue : 6  |  Page : 388-403

Obesity: An insight into its neurochemical basis and treatment



Correspondence Address:
S K Kulkarni


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Obesity threatens to become the 21st century's leading health problem. Its prevalence is on the rise in all age groups and in all developed countries of the world. The exact aetiology of obesity still remains obscure. It is mainly caused by a combination of genetic factors, inappropriate eating and reduced activity. Besides, dysregulation of various hypothalamic mechanisms controlling energy intake and energy expenditure have also been implicated in its development and progression. In the last few years, steady advances made in the understanding of the body's weight regulating mechanisms has helped to define novel sites for targeting and intervention in order to reduce intake and enhance expenditure. Based on this, many new antiobesity drugs have been developed. Some of them are in the early stages of development and some of compounds acting on these sites are already available.






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