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 RESEARCH PAPER
Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 363-366

Study on analgesic and anti-inflammatory activities of Vitex negundo Linn



Correspondence Address:
R S Telang


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Objective : To evaluate the analgesic and antiinflammatory activities of hydroalcoholic extract of Vitex negundo leaves and to elucidate possible mechanism(s) of its pharmacological activities. Methods : The analgesic activity of Vitex negundo leaf extract (VLE) [500 and 1000 mg/kg] was studied using acetic acid induced writhing test in mice for assessing peripheral analgesic effect and tail immersion test in mice for assessing central analgesic effect. The antiinflammatory activity of VLE (500 and 1000 mg/kg) was studied by using the models of carrageenin-induced rat paw oedema and carrageenin-induced granuloma pouch in rats for assessing the effect on acute and subacute inflammations, respectively. Isolated rat uterus was used to study the involvement of prostaglandins in the analgesic and antiinflammatory activities of VLE. The chemical analysis of the VLE was done using HPTLC technique. Results : VLE significantly increased the reaction time and decreased the writhing movements in mice in acetic acid-induced writhing test. There was a significant increase in the reaction time in tail immersion test. VLE significantly decreased the rat paw oedema volume at higher dose. It also significantly decreased the formation of granuloma pouch in rats. VLE had inhibitory action on oxytocin-induced contractions in isolated horns of uterus primed with oestradiol. Bioflavonoids were found to be present in VLE. Conclusion : VLE may have both central and peripheral analgesic action. VLE also possesses antiinflammatory activity which was more pronounced on subacute rather than on acute inflammation. The analgesic and anti- inflammatory action of VLE can be attributed to its flavonoid contents, which are known to act through inhibition of prostaglandin biosynthesis.






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