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 RESEARCH PAPER
Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 345-349

K + - channel openers potentiate the inhibitory effect of atropine on contractile response induced by electrical field stimulation in rat urinary bladder



Correspondence Address:
A G Telang


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Objectives: To study the inhibitory effect of pinacidil and cromakalim on the contractile response induced by electrical field stimulation (EFS) in atropinized rat urinary bladder strip. Methods: The rat urinary bladder strips were stimulated by two parallel platinum wire electrodes. Electrical impulses for field stimulation of intrinsic nerves were delivered for 1ms duration at 60v and frequency ranging from 0.5-64 Hz. The control contractile response to EFS was evoked by the application of 5sec trains of impulses at a constant frequency. The effect of pinacidil and cromakalim on the contractile responses induced by EFS on atropinized tissues was evaluated. Results: The mean EF50 value of frequency related contractile response curve was ranging from 3.45- 3.92 Hz. In presence of pinacidil and cromakalim the EF50 values were significantly higher than that of their corresponding control EF50 values. In presence of atropine, pinacidil and cromakalim further increased the EF 50 values. Conclusion: K+ - channel openers in atropinized rat urinary bladder smooth muscle potentiate the inhibitory effect of atropine on contractile response induced by EFS.






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