|Year : 1999 | Volume
| Issue : 3 | Page : 242-243
Potentiation of antiulcer effect of famotidine by calcium channel antagonists-a pharmacodynamic or pharmacokinetic interaction
Objective: To study the neuropsychobehavioural effects of traditional silver preparations: Raupya Bhasma, Kushta Nuqra and Chandi Warq.
Methods: The preparations were subjected to a battery of 30 tests for general neuropsychopharmacological effects, cognitive functions, antidepressant, anxiolytic, neuroleptic and serenic activities, effects on growth, body weight, endurance and fatigue.
Results: The test drugs (50 mg/kg, p.o.) caused significant reduction of haloperidol-induced catalepsy in rats. Incorporation in the diet of rat pups (1% w/w for 6 weeks) lead to significantly higher growth rate when compared to control animals. No appreciable effects were discernible on other parameters.
Conclusion: Silver preparations used in Ayurveda and Unani-Tibb showed anticataleptic and growth promoting effects without gross or subtle toxicities, weight loss, sedation, motor deficit, aggression or ill effects on cognitive functions.
M C Gupta
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