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 RESEARCH PAPER
Year : 1999  |  Volume : 31  |  Issue : 3  |  Page : 222-224

Pharmacological studies of isomeric juglones on the isolated frog heart



Correspondence Address:
S H Bhosale


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Source of Support: None, Conflict of Interest: None


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Objective: To study the effect and mechanism of action of Isomeric Juglones on the isolated frog heart. Method: The response of dosage forms of four Isomeric Juglones namely juglone, plumbagin, lawsone and phthiocol were investigated on isolated frog heart preparation. Their interaction with calcium channel blockers namely verapamil, nifedipine and diltiazem was studied to elucidate the mechanism of action. Result: Administration of juglone (10-100 mcg), lawsone (10 mcg -1 mg) plumbagin (1-100 mcg) and phthiocol (1-80 mcg) showed dose dependent increase in the rate of contraction and force of contraction of heart. The positive inotropic action of juglone (40 mcg), lawsone (80 mcg), plumbagin (8 mcg) and phthiocol (80 mcg) was blocked by verapamil (1 mcg), nifedipine (5 mcg) and diltiazem (10 mcg). Conclusion: The Isomeric Juglones showed positive inotropic and chronotropic action on the frog heart. The mechanism of action of these Isomeric Juglones indicated involvement of calcium channels.






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