| RESEARCH PAPER
|Year : 1999 | Volume
| Issue : 3 | Page : 200-203
Uterine tonic activity of U-3107, a herbal preparation, in rats
SK Mitra, S Gopumadhavan, MV Venkataranganna, DNK Sarma, SD Anturlikar
Objectives: To evaluate the oestrogenic effect of U-3107, a herbal uterine tonic using in vivo and in vitro experimental models.
Methods: Oestrogenic effect of U-3107 (1 gm/kg p.o.) was studied in normal and ovariectomized rats. U-3107 was administered as an aqueous suspension for a period of 21 days. The parameters studied in both in vivo models included uterine weight (wet and dry weight), oestrogen and progesterone levels. The effect of U-3107 (1 gm/kg p.o. x 21 days) was also studied in normal rats on regular oestrus cycle. In vitro studies with U-3107 (50-400 (g/ml of aqueous extract) on isolated uterus in non-gravid, nonoestronised rats were carried out to find out whether the formulation possesses any oxytocin like activity.
Results: Administration of U-3107 in normal rats significantly increased the wet and dry uterine weight. It also resulted in marked increase of oestrogen levels with no change in progesterone levels as compared to control. U-3107 treatment in ovariectomized rats did not show any increase in uterine weight. The rats from both control and treated group showed normal oestrus cycle. Aqueous extract of U-3107 failed to produce contractile response on the uterus when exposed in vitro and decreased spasmogen-induced contraction.
Conclusion: U-3107 possess oestrogenic activity only in the presence of functional ovary and is devoid of any progestational activity.
S K Mitra