IPSIndian Journal of Pharmacology
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Year : 1999  |  Volume : 31  |  Issue : 3  |  Page : 187-189

Effect of calcium channel blockers on aluminium treated rat brain serine/threonine phosphoprotein phosphatase 2B


Correspondence Address:
Basu Srabanti

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Source of Support: None, Conflict of Interest: None

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Objectives: To examine the effect of aluminium (Al) on different types of phosphatases in rat brain in the presence and absence of Ca 2+ channel blockers. Methods: Phosphoprotein phosphatase activities were measured in brains of male Sprague Dawley rats treated with aluminium chloride (AlCl3 ) , Ca2+ channel blockers per se and AlCl3 with Ca2+ channel blockers for 40 days using standard techniques. Results: Tyrosine phosphoprotein phosphatase (TPP) activity, activation of TPP by EDTA and activity of serine/threonine phosphoprotein phosphatase 2B (PP2B) were decreased by Al. Nifedipine treated rats regained the activities of TPP and PP2B and showed increased activity of serine/threonine phosphatase 2C (PP2C). Verapamil and diltiazem were ineffective in restoring the normal activities of the enzymes. Conclusion: The restoration of the activity of PP2B by nifedipine indicates that there may be a competition between Al and Ca and between Al and Ca2+ channel blocker nifedipine. Hence the Ca 2+ channel blocker nifedipine can be used to prevent Al 3+ toxicity.


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