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 SHORT COMMUNICATION
Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 146-149

Inhibition of nitric oxide synthase by Nw-nitro-l-arginine overcomes delayed intestinal transit in streptozotocin-induced diabetic mice



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B M Patil


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Objectives: To characterize the changes in intestinal transit induced by diabetes and the implication of nitric oxide in such changes. Methods: Diabetes was induced in mice by single injection of streptozotocin (STZ 160 mg/kg, ip). One, four and six weeks later, intestinal transit was measured after pretreatment with saline or drug, using charcoal meal method. Results: Intestinal transit was significantly reduced in 1, 4 and 6 weeks STZ diabetic mice as compared with normal mice. Treatment with N(-nitro-L-arginine (10,20and 25 mg/kg, ip ) dose dependently increased the intestinal transit in STZ-diabetic mice. Increased intestinal transit effect of N(-nitro-L-arginine (20 mg/kg) was dose dependently reversed by L-arginine (300, 600 and 900 mg/kg ) but not by D-arginine (600 mg/kg ). Conclusion: In the early stages of STZ diabetes, there may be an enhanced production of nitric oxide, which could account for reduced intestinal transit in diabetes.






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