IPSIndian Journal of Pharmacology
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Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 133-137

Antiasthmatic and antianaphylactic effect of E-721B, a herbal formulation

Correspondence Address:
S K Mitra

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Source of Support: None, Conflict of Interest: None

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Objective: To evaluate the antiasthmatic and antianaphylactic activity of E-721B in various experimental models. Methods: The antiasthmatic and antianaphylactic activity of E-721B was studied on the active and passive anaphylaxis in rats, acetyl choline-induced bronchospasm in guinea pigs, anaphylactic shock-induced bronchospasm in guinea pigs and rats and on degranulation of mast cells by Compound 48/80. Results: Treatment with E-721B showed a dose dependent (at 50, 100, 250 and 500 mg/kg p.o.) beneficial effect on degranulation rate of actively and passively sensitized mesenteric mast cells of albino rats when challenged with antigen (horse serum). E-721B treatment for 7 days resulted in significant protection against acetylcholine aerosol-induced bronchospasm in guinea pigs. E-721B treatment for 10 and 14 days, in guinea pigs and rats respectively, offered marked protection against anaphylactic shock-induced bronchospasm. E 721B treatment also protected the mast cell disruption induced by Compound 48/80. Conclusion: Antiasthmatic and antianaphylactic activity of E-721B may be possibly due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release.


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