| RESEARCH PAPER
|Year : 1999 | Volume
| Issue : 2 | Page : 133-137
Antiasthmatic and antianaphylactic effect of E-721B, a herbal formulation
SK Mitra, S Gopumadhavan, MV Venkataranganna, SD Anturlikar
Objective: To evaluate the antiasthmatic and antianaphylactic activity of E-721B in various experimental models.
Methods: The antiasthmatic and antianaphylactic activity of E-721B was studied on the active and passive anaphylaxis in rats, acetyl choline-induced bronchospasm in guinea pigs, anaphylactic shock-induced bronchospasm in guinea pigs and rats and on degranulation of mast cells by Compound 48/80.
Results: Treatment with E-721B showed a dose dependent (at 50, 100, 250 and 500 mg/kg p.o.) beneficial effect on degranulation rate of actively and passively sensitized mesenteric mast cells of albino rats when challenged with antigen (horse serum). E-721B treatment for 7 days resulted in significant protection against acetylcholine aerosol-induced bronchospasm in guinea pigs. E-721B treatment for 10 and 14 days, in guinea pigs and rats respectively, offered marked protection against anaphylactic shock-induced bronchospasm. E 721B treatment also protected the mast cell disruption induced by Compound 48/80.
Conclusion: Antiasthmatic and antianaphylactic activity of E-721B may be possibly due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release.
S K Mitra
Source of Support: None, Conflict of Interest: None