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 RESEARCH PAPER
Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 128-132

Protective effect of rhinax, a herbal formulation against physical and chemical factors induced gastric and duodenal ulcers in rats


Correspondence Address:
J N Dhuley


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Source of Support: None, Conflict of Interest: None


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Objective: To investigate the ulcer-protective effect of Rhinax (a herbal formulation) in rats. Methods: The study was done in male albino rats. Gastric ulcers were induced by exposing rats to cold restraint stress or by oral administration of aspirin / alcohol. The stomach was incised along the greater curvature and examined for ulcers. Duodenal ulcers were induced by injecting (s.c.) cysteamine hydrochloride. Duodenum was examined for the presence or absence of ulcers. Effect of Rhinax on volume, pH, free and total acid content of gastric juice in pylorus ligated rats was also determined. In addition, effect of Rhinax on gastric mucus barrier in rats was determined and histological examination of gastric glandular mucosa carried out employing alcian blue stain. In this study, each group in each experiment consisted of 8 animals. Results: Oral administration of Rhinax resulted in promotion of gastric mucus secretion in normal as well as in cold restraint stress, drug and alcohol - induced ulceration in rats. The volume and acidity of gastric juice in pyloric ligated rats was also reduced by Rhinax administration. Conclusion: All the results suggest that Rhinax possessess ulcer - protective activity which is evoked mainly by the modulation of defensive factors by improvement in gastric cytoprotection and partly by acid inhibition and free radical scavenging properties.






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