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 RESEARCH PAPER
Year : 1999  |  Volume : 31  |  Issue : 1  |  Page : 29-32

A comparative experimental study of proconvulsive potential of fluoroquinolones



Correspondence Address:
Rewari Shalini


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Objective: To compare the proconvulsive potential of some currently available fluoroquinolones namely ciprofloxacin, ofloxacin and pefloxacin on electro convulsion and chemoconvulsion in rats and mice respectively and to correlate the same with the clinical reports. Methods: The animals were treated intraperitoneally with 12.5 and 25mg/kg, of ciprofloxacin, ofloxacin or pefloxacin and then subjected to maximal electroshock seizures (MES), subconvulsive doses of pentylenetetrazole(PTZ) and theophylline (40 and 125mg/kg. i.p. respectively). Results: Ciprofloxacin and pefloxacin employed in the higher dose had significant worsening effect on MES. Tonic extensor phase was prolonged from 11.6 ( 0.4 secs in control group to 38.11( 5.38 secs and 23.5 ( 4.5 secs with higher doses of ciprofloxacin and pefloxacin respectively, while both the doses of ofloxacin had no statistically significant effect on this parameter. On administration of subconvulsive dose of PTZ, both the doses of ofloxacin and higher doses of ciprofloxacin and pefloxacin showed significant worsening effect. Lastly, on coadministration with theophylline both the doses of ofloxacin and higher dose of pefloxacin had significant proconvulsant effect. Ciprofloxacin in both the doses did not show any significant proconvulsant effect. Conclusion: The results indicate that all the three fluoroquinolones especially ofloxacin should be used with caution in patients with predisposing epileptogenic factors. Also the model of chemoconvulsions showed better clinical correlation for proconvulsive property of fluoroquinolones.






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