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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 6  |  Page : 399-403

Effect of Abana, an ayurvedic preparation on ethinyl estradiol-induced hypertension in rats



Correspondence Address:
J D Bhatt


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0bjectives:To study the effect of Abana, an ayurvedic herbomineral preparation on blood pressure and vascular reactivity to noradrenaline (NA), acetylcholine (ACh) and isoprenaline (Iso) in normotensive control and ethinyl estradiol (EE)-induced hypertensive rats. Methods: Animals were divided into six groups receiving different treatments consisting of vehicle, EE (1.5 mg/kg/day i.m.) and Abana (3 g/kg/day orally) either alone or in combination for 3 or 6 weeks. After completion of the treatment schedules, effect of ACh, NA and Iso on the blood pressure and vasopressor effects of NA on the hindquarter preparation was studied. Dopamine-(-hydroxylase (DBH) activity was also measured in adrenal glands after completion of the different treatments. Results: Abana treatment for 3 weeks to normotensive rats produced significant lowering of blood pressure, enhancement of vasopressor response to low dose of NA (0.5 'g/kg IV). However, DBH activity of the adrenal glands and vasodepressor responses to ACh and Iso were not altered in Abana-treated rats. Combined treatment with Abana and EE for 3 weeks or pretreatment with Abana for 3 weeks followed by the combined treatment prevented EE-induced hypertension and increased the DBH activity of the adrenal glands. Also the altered vascular reactivity to NA (0.5 'g/kg IV) observed in EE-treated and Abana-treated groups were abolished in the groups receiving the combined treatments. Conclusion: It is suggested that Abana produced protective effects against EE-induced hypertension in rats probably by its sympathetic blocking property.






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