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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 6  |  Page : 390-393

Potentiation of gastric antiulcer effect of famotidine by calcium channel blockers in rats



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S Mandal


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0bjective:To study the gastric antiulcer effect of low doses of calcium channel blockers (CCB) namely, nifedipine, verapamil and diltiazem on potentiation of antiulcer and antisecretory effect of famotidine by them. Methods: Gastic ulcers were induced in rats by restraint, aspirin treatment and pyioric ligation.The ulcer score, volume of secretion and pH were recorded. Results: Nifedipine (200 'g/100 g) and verapamil (1 mg/100 g) produced a significant reduction in the ulcer score. However, diltiazem at a dose of 600 'g/100 g did not produce any effect on the ulcer score. All the three CCBs potentiated the antiucler and antisecretory effect of famotidine at doses which were ineffective in reducing the gastric ulceration when given alone. Conclusion: Nifedipine and verapamil offered a protective effect against gastric ulceration. Nifedipine, verapamil and diltiazem potentiate the antiulcer and antisecretory effect of famotidine at low doses. Based on these findings it may be speculated that the dose of famotidine could be reduced in patients receiving CCBs.






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