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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 6  |  Page : 379-384

Evaluation of the antiulcer activity of cromakalim, a potassium channel opener, in experimentally induced acute and chronic gastric ulcers



Correspondence Address:
Goswami Sailendra


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Source of Support: None, Conflict of Interest: None


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0bjective:To evaluate the antiulcer activity of cromakalim, a potassium channel opener, using various experimentally induced acute and chronic gastric ulcer models and to elucidate possible mechanism(s) of its antiulcer activity. Methods:The antiulcer activity of cromakalim (200 'g/kg, p.o.) was studied using experimentally induced acute gastric ulcer models such as aspirin plus pylorus-ligation, ethanol-induced acute gastric ulcers in rats and acetic acid-induced chronic gastric ulcerations in rats. In all the models studied, the antiulcer activity of cromakalim was compared with that of cimetidine (50 mg/kg, p.o.), an H2 receptor antagonist, In the aspirin plus pylorus-ligation model, the parameters studied were the ulcer index. the volume of gastric content, total acidity, total acid output, pepsin activity, total carbohydrate content (sum of total hexoses, hexosamine, fucose and sialic acid), total protein content and mucin activity. In ethanol-induced gastric ulcer model, the parameter studied was the ulcer index. In the acetic acid-induced chronic gastric ulcer model, the parameters studied were the ulcer index, total lesion area and score for intensity of gastric lesions. Results: In the aspirin plus pylorus-ligation model, cromakalim pretreatment caused a significant reduction in the ulcer index when compared with the control (aspirin plus pylorus-ligated) group. It has shown a significant reduction in the acid secretory parameters i.e. total acidity and pepsin activity whereas an increase in the volume of gastric content in the cromakalim-treated group led to an insignificant increase in total acid output when compared with the control group. Moreover, cromaklim did show an insignificant rise in mucin activity (total carbohydrates to protein ratio). In all the parameters, cimetidine showed a significant protective effect against ulcerations. Both cromakalim and cimetidine showed a significant reduction in the ulcer index against ethanol-induced gastric ulcerations in rats showing their cytoprotective activity. In the acetic acid-induced chronic gastric ulcer model, cromakalim showed a significant reduction in the ulcer index, total lesion area and score for intensity of gastric ulcerations and these results were comparable with those of cimetidine. Conclusion: Cromakalim possesses antiulcer activity against both acute and chronic gastric ulcer models and these results were comparable with those of cimetidine. The antiulcer activity of cromakalim can be attributed to its cytoprotective action and inhibition of the acid secretory parameters.






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