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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 5  |  Page : 311-317

Immunomodulatory and antineoplastic activity of common Indian toad (Bufo melanostictus, Schneider) skin extract



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Das Manika


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Objective : To explore the immunomodulatory and antineoplastic action of toad skin extract (TSE) in experimental animals Methods: TSE was injected (s.c.) in male albino mice. Lymphocyte (blood and spleen) and macrophage count were done at different time intervals. To estimate phagocytic activity carbon clearance assay was performed in albino mice. Effect of TSE on T-cell rosette, chemotaxis of leucocyte, and macrophage migration was also studied in vitro. To study antineoplastic activity, TSE was injected (i.p.) in Ehrlich Ascites Carcinoma (EAC) bearing mice. Survival time and tumour cell growth (in vivo) were estimated. Results : TSE significantly increased lymphocyte (blood and spleen) and macrophage count. TSE significantly increased phagocytic activity and showed positive meutrophil chemotaxis in vitro. Enhanced inhibition of macrophage migration and T-cell rosette formation was observed due to TSE. TSE also increased survivial time of EAC bearing mice and inhibited tumour cell growth in vivo. Conclusion :All these observations indicate that TSE possesses immunomodulatory and antineoplastic activity in experimental animals.






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