IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3265 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1273    
    Printed83    
    Emailed0    
    PDF Downloaded148    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 2  |  Page : 94-96

An experimental and clinical evaluation of immunomodulating potential of ascorbic acid



Correspondence Address:
K U Ansari


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objectives: To find the effects of ascorbic acid on immune system in rabbits and human volunteers. Methods: In humans, humoral immunity was measured by immunoglobulin estimation (IgG, IgM, IgA) using tripantigen plates and cell mediated immunity by total lymphocyte count and T-cell count. In rabbits, widal agglutination test using typhoid-H antigen and Dinitro chlorobenzene (DNCB) and tuberculin skin sensitivity tests were performed as measurement of humoral and cell-mediated immunity, respectively. Result: Administration of ascorbic acid 500 mg thrice daily orally for 21 days increased serum immunoglobulin in human subjects. In rabbits, ascorbic acid administration in the dose of 200 mg/kg/day orally for 21 days caused a rise in antibody titre. No effect on cell mediated immunity was found in human as well as animal models. Conclusion: Ascorbic acid appears to stimulate humoral immunity through increased antibody synthesis particularly IgG, IgA and IgM types and also by activating the macrophages.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow