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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 2  |  Page : 73-81

Antioxidant status of S-Allyl cysteine sulphoxide on monosodium glutamate potentiated atherogenesis



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K N Bopanna


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Objective : To study the effect of S-allyl cysteine sulphoxide (SACS) in rats on atherogenic diet with monosodium glutamate. Methods : Rats on atherogenic diet with monosodium glutamate (MSG) at two doses received SACS for thirty days. At the end of thirty days malondialdehyde, hydroperoxide, conjugated diene and reduced glutathione content were estimated in the heart, liver, kidney, lung and brain. Super oxide dismutase (SOD) and catalase levels were analysed in heart, liver and kidney. Results : SACS significantly decreased the concentration of malondialdehyde, hydroperoxides and conjugated diene in liver and heart in rats treated on MSG (250 mgkg). There were no significant changes observed by SACS in rats on MSG (1g/kg) as well as effect of SACS on MSG (250mg/kg) in lungs, kidney and brain. Reduced glutathione (GSH), SOD and Catalase levels were increased in liver, kidney and heart in rats on SACS. Conclusion : SACS produces a significant antioxidant effect in atherogenic rats on lower dose of MSG.






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