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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 1  |  Page : 34-37

Differential effects of phenobarbitone on the hepatic and renal glutathione-s-transferases in the rhesus monkey



Correspondence Address:
K V Ramana


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Objective: To comprehend the differential effects of phenobarbitone (PB) on the hepatic and renal glutathione-Stransferases (GSTs). Methods: Male rhesus monkeys were administered PB intraperitoneally at a dose of 50 mg/Kg body weight/day for four days. Livers and kidneys were homogenized and 100,000 x g supernatant were prepared. The assays of GSTs using 1 chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitro-benzene (DCNB) and ethacrynic acid (EA) were performed in the supematant obtained from control and PB pretreated macaques. Results: PB caused a statistically significant decrease in the specific activity of hepatic GST towards CDNB (49%) and DCNB (64%) and a nonsignificant decrease towards EA (22%). In the kidney, the specific activities of GSTs towards these substrates were decreased by PB to a lesser extent (CDNB, 28%; DCNB, 11%; and EA, 18%) and were statistically nonsignificant. Conclusion: PB decreases the activity of hepatic GSTs significantly and that of renal GSTs non-significantlv in the rhesus monkev. These observations are surprising in the context that PB is a well known inducer of GSTs in the rodents.






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