| RESEARCH PAPER
|Year : 1998 | Volume
| Issue : 1 | Page : 16-20
Anti-cataract activity of Ocimum sanctum on experimental cataract
P Sharma, S Kulshreshtha, AL Sharma
Objective: To study the effect of Ocimum sanctum (Tulsi) on experimental cataract in rats and rabbits.
Methods: Two models of experimental cataract were induced: (1) Galactosaemic cataract in rats by 30% galactose, (2) Naphthalene cataract in rabbits by 1 gm/kg naphthalene. Ocimum sanctum (O.S.) was administered orally in both models at two dose levels 1 and 2 gm/kg of body weight for curative and prophylactic effects. The study was conducted for 40 days.
Results: O.S. delayed the onset of cataract as well as the subsequent maturation of cataract significantly in both models. In addition to delay in reaching various stages of development of cataract, IV stage did not develop with high doses till completion of 40 days of experimental period.
Conclusion: O.S. delayed the process of cataractogenesis in both models. The higher doses are more effective and have not promising prophylactic role rather than curative one. This effect is more clear in galactosaemic catract.
Source of Support: None, Conflict of Interest: None