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 RESEARCH PAPER
Year : 1997  |  Volume : 29  |  Issue : 6  |  Page : 416-419

Modulation of brewer’s yeast-induced peripheral inflammation and nociception in rats by centrally administered prostaglandins and their inhibitors



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S K Hore


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Objective: To study the effect of centrally administered prostaglandins and cyclooxygenase inhibitors on Brewer's yeast-induced peripheral inflammation and nociception. Methods: Intracerebroventricular (ICV) cannulation was performed in rats. Arachidonic acid, PGE2 PGF2( paracetamol. aspirin and indomethacin were administered centrally, before acute inflammation was Induced by Brewer's yeast. The hind paw oedema volume and pain threshold were measured by plethysmometer and analgesiometer, respectively. Results: PGF2( paracetamol, aspirin and indomethacin significantly suppressed the paw oedema volume at various periods of inflammatory process. Arachidonic acid and PGE2 reduced the pain threshold while, paracetamol and aspirin significantly augmented the pain threshold. Conclusion: Centrally administered PGF2( effect on Brewer's yeast-induced acute inflammation and pain, providing evidence of involvement of 29 exerts anti-inflammatory while, PGE2 exerts pronociceptive CNS in modulation of peripheral inflammation and pain.






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