IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3407 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1500    
    Printed93    
    Emailed0    
    PDF Downloaded186    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 244-249

Enhancement of the cytotoxic effects of echitamine chloride by vitamin A: An in vitro study on Ehrlich ascites carcinoma cell culture



Correspondence Address:
Viswanathan Saraswathi


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objectives: A study was conducted to examine the in vitro cytotoxic effects of Echitamine chloride (EC), a plant alkaloid extracted from the bark of Alstonia scholaris. Since vitamin A was found to enhance the anticancer effects of several anticancer drugs, the synergistic effects of these two drugs were also studied. Methods: Echitamine chloride at a concentration of 200'M and Vitamin A at a concentration of 10 'M were added alone as well as in combination to the Ehrlich Ascites Carcinoma (EAC) cell cultures. Cell viability, antioxidant enzyme status, lipid peroxidation and 3H -Thymidine incorporation were studied. Results: The cultures treated with EC and vitamin A combination showed significant cytotoxic effect than the cultures treated with individual drugs. Conclusion: It may be concluded that EC in combination with vitamin A has an enhanced cytotoxic effect on Ehrlich Ascites Carcinoma cell culture.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow