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 RESEARCH PAPER
Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 238-243

Effect of 1-chloroacetophenone (CN) and dibenz (b,f)-1,4 oxazepine (CR) vapour inhalation on some cardiovascular and respiratory variables in anaesthetised rats



Correspondence Address:
Kumar Pravin


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Objectives: The study was aimed at investigating the effects of inhalation of pyrotechnically generated vapours of two riot controlling agents on some selected physiological variables in rats. Methods: Known quantity of the individual compounds were heated by Bunsen flame and generated vapour was purged into specially designed and fabricated exposure chamber. The animals were allowed to inhale the vapour (for 5 minutes; 1 LC50 or 3 LC50) through tracheal cannula. The effects thus induced in anaesthetized and tracheostomised male rats on blood pressure, heart rate, electrocardiogram, respiratory rate, tidal volume and neuromuscular junction were recorded and analysed. Results: A significant dose dependent fall in mean arterial pressure (MAP) and bradycardia were observed following CN exposure. Pretreatment of atropine sulphate or prior bilateral vagotomy, significantly prevented these changes while atropine methylnitrate was found to be ineffective. CR at equitoxic concentration, induced dose dependent fall in MAP and bradycardia but of low magnitude, and the changes were blocked by pretreatment of atropine sulphate or atropine methylnitrate. The other physiological variables viz. electrocardiogram, respiratory rate, tidal volume and transmission of impulses across the neuromuscular junction remained unaltered. Conclusion: It may be concluded that CN induced hypotension is mediated through central muscarinic cholinergic receptors, while in case of CR the effects are of low magnitude at equitoxic dose level, and are through primarily peripheral muscarinic receptors.






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