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 RESEARCH PAPER
Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 228-232

Role of benzodiazepine-GABA receptor complex in stress - induced modulation of leucocyte migration inhibition factor



Correspondence Address:
P K Mediratta


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Objectives: To investigate the role of benzodiazepine-GABA receptor mechanisms in stress-induced modulation of leucocyte migration inhibition factor (LMIF), a lymphokine released from sensitized lymphocytes. Methods: Groups of male Wistar rats (n = 6 in each group) were subjected to restraint stress (RS) for 24 h at room temperature on day -1 (one day before), +1 or +13 (one or 13 days after) of sensitization with 0.5 ml of egg albumin (25 mg/ml) and 0.5 ml of complete Freund's adjuvant. Drugs/vehicle were injected i.p. just before submitting the animals to RS and LMIF activity was measured on day +14 by leucocyte migration inhibition (LMI) test. Results: RS per se increased % LMI when given on day -1 but reduced it when administered on day +l and +13. Diazepam (5 mg/kg), muscimol (1 mg/kg) and baclofen (5 mg/kg) significantly attenuated the effect of RS on % LMI. The effect of diazepam was blocked by both flumazenil (10 mg/kg) and bicuculline (2 mg/kg); the latter also antagonised the effect of muscimol. Conclusion: GABA-ergic mechanisms, mediated at both GABAA and GABAB receptors appear to play a role in the regulation of RS-induced changes in release activity of LMF.






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