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 RESEARCH PAPER
Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 222-227

Further studies on the antihepatotoxic activity of jigrine



Correspondence Address:
N Karunakar


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Source of Support: None, Conflict of Interest: None


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Objectives: To evaluate the anti-hepatotoxic activity of Jigrine (a Unani polypharmaceutical herbal formulation) against alcohol and CCl4 induced hepatotoxicity in rats. Methods: Albino rats (Wistar strain) were given alcohol (40% alcohol, 2.0ml/100g, po for 21 days) and CCl4 (1:1 in groundnut oil, 0.1ml/kg, SC on 20th day) to induce hepatotoxicity. Jigrine at two dose levels (0.5ml and 1.0ml/kg, po) was given for a period of 7 days (i.e. 15th to 21st day) to the rats treated with alcohol and CCl4. Silymarin (25mg/kg, po) was given as a reference drug. Biochemical parameters like serum AST, ALT, tissue (-GTP, triglycerides and lipid peroxides were estimated to assess the liver function. Histopathological studies were also done to confirm the biochemical changes, Results: The mean ˝ SEM serum AST, ALT levels in control animals were 44.4 ˝ 5.7 Units/ml and 55.2 ˝ 7.9 Units/ml, where as in alcohol - CCl4 treated rats the levels rose to 234 ˝ 4.6 Units/ml and 122.4 ˝ 21.9 Units/ml. Jigrine at two dose levels reduced the AST and ALT levels to 190.8 ˝ 7.6 Units/ml; 87.2 ˝ 15.6 Units/ml and 160.4 ˝ 9.9 Units/ml; 68.8 ˝ 6.4 Units/ml. Silymarin reduced AST and ALT levels to 136 ˝ 13.4 Units/ml and 64 ˝ 5.3 Units/ml. The tissue mean ˝ SEM of ( -GTP, triglycerides and TBARS in control animals were 40.9 ˝ 3.2 I.U; 26.5 ˝ 4.5 mg/100ml and 1.44 ˝ 0.2 n.mole MDA/mg protein, where as in alcohol -CCl4 treated rats the levels rose to 122.25 ˝ 5.3 I.U; 174 ˝ 12.6 mg/100ml and 7.65 ˝ 0.7 n.mole MDA/mg protein. Jigrine (0.5ml/kg, po) reduced the ( -GTP to 84.13 ˝ 7.2 I.U; triglycerides to 118.5 ˝ 12.8 mg/100ml and TBARS to 3.69 ˝ 0.6 n.mole MDA/mg protein. Jigrine (1ml/kg, po) reduced the y GTP to 69.07 ˝ 13.1 I.U; triglycerides to 84 ˝ 14.8 mg/100ml and TBARS to 1.81 ˝ 0.17 n.mole MDA/mg protein. Silymarin (25mg/kg, po) reduced the ( -GTP to 64.5 ˝ 12.4 I.U; triglycerides to 60 ˝ 9.1 mg/100ml and TBARS to 2.33 ˝ 0.2 n.mole MDA/mg protein. Conclusion: The study confirms the antihepatotoxic activity of Jigrine which may be attributed to the membrane stabilizing and antioxidant property of this medicine.






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