| SHORT COMMUNICATION
|Year : 1997 | Volume
| Issue : 3 | Page : 194-197
The anticonvulsant effect of pentazocine against maximal electroshock seizure in mice
Manocha Anshu, KK Sharma, PK Mediratta
Objectives: The present study was designed to investigate whether pentazocine protects against electrically-Induced seizures in mice. An attempt was also made to determine the possible opioid receptor mechanism involved.
Methods: Maximal electroshock (MES) seizures were induced in mice via transauricular electrodes (60 mA, 0.2 sec). Seizure severity was assessed by the duration of hindlimb extensor phase.
Results: lntraperitoneal administration of pentazocine resulted in a dose dependent inhibition of the hind-limb extensor phase during the MES. The ED50for the effect was found to be 15 mg/kg. The anticonvulsant effect of pentazocine was completely antagonized by the high doses (1.O mg/kg, 5.0/kg), but not by the low doses (0.1 mg/kg, 0.25mg/kg) of i.p. naloxone.
Conclusion: The results suggest that the anti-MES effect of pentazocine is mediated by k-receptors, since naloxone in high doses is known to block these receptors.
Source of Support: None, Conflict of Interest: None