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 SHORT COMMUNICATION
Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 190-193

Modulatory role of central purinergic neurotransmitters on Brewer’s yeast-induced inflammation in rats



Correspondence Address:
S K Hore


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Objective: To study the effect of centrally administered adenosine, ATP and caffeine on Brewer's yeast-induced peripheral inflammation and nociception in rats Methods: ICV cannulation was performed in rats. ATP (50 'g), adenosine (50 'g) and caffeine (20 'g) were administered centrally, 30 min before administration of phlogistic agent. Acute inflammation was induced by administration of Brewer's yeast suspension below the plantar aponeurosis of hind paw of rats. The hind paw oedema volume and pain threshold were measured by plethysmometer and analgesiometer respectively. Results: ATP showed significant inhibition of Brewer's yeast-induced pedal oedema with concomitant reduction of protein content of exudate. However, adenosine, in addition attenuated pain. Caffeine did not alter the oedema volume, protein content of the exudate or pain threshold. Conclusion: The present study suggests that central purinergic system exerts anti-inflammatory effect and confirms the involvement of CNS in modulating peripheral inflammation.






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