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 RESEARCH PAPER
Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 157-161

Antineoplastic activity of copper-benzohydroxamic acid complex against Ehrlich ascites carcinoma (EAC) in mice



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J A Khanam


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Objective: To study the effect of copper benzohydroxamic acid complex (CU-BHA) against Ehrlich ascites carcinoma (EAC) in Swiss A mice. Methods: CU-BHA complex was synthesized from benzohydroxamic acid and CuSO4 solution. Swiss A mice inoculated with EAC cells were treated with the Cu-BHA complex and their longivity was compared with the untreated control group. Different biochemical parameters (alkaline phosphatase activity and lipid peroxidation in serum) and haematological parameters were noted. Transplantability of CU-BHA complex treated EAC cells were observed. Results: CU-BHA complex (25 mg./kg) enhanced longivity of tumour bearing mice significantly. Transplantability of EAC cells were reduced by Cu-BHA treatment. Haematological parameters and serum alkaline phosphatase activity in tumour bearing mice were found to be significantly altered but, Cu-BHA treatment recovered those parameters towards normal values. Conclusion: The CU-BHA complex was found to be a potential antitumour drug. The tumour bearing mice treated with this complex showed negligible host-toxicity.






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